Seminars and Events

The seminars below are open to the public. Seminars will be held on the date noted at 11:45 AM in Room 141 Hughes (unless otherwise indicated). Refreshments will be served at 11:30 AM. Parking is available across the street or in the North Campus Parking Garage. If there are any questions, please contact: Dr. Rick Page at pagerc@miamioh.edu.

August 10, 2017 | Laura Sagle, University of Cincinnati

Combining Plasmonic Particles And Lipids For Biosensing And Spectroscopy

This presentation will highlight two platforms recently developed in the Sagle group which combine lipids and plasmonic nanoparticles.  The first platform involves sandwiching a liposome between a planar gold surface and a gold colloid to generate a biocompatible, highly enhancing surface enhanced Raman spectroscopy (SERS) substrate.  Our initial characterization of these novel substrates investigates substrate stability, temperature inside the liposome component, SERS activity, and mechanism and reproducibility.  The substrates are shown to be stable to laser irradiation and exhibit a temperature increase of only 20 degrees Celsius inside the liposome component.  The SERS enhancement of dye residing in the liposome component was found to be 8 x 106, higher than expected considering the dye molecules are at least 4 nm from either gold surface.  Finite Difference Time Domain (FDTD) calculations reveal that the field enhancements inside the liposome are uniform with the major contributing factor being long range coupling between the gold nanoparticle and the mirror.  Lastly, these substrates show greater reproducibility than typical SERS substrates in which dye is sandwiched between two metallic surfaces, and are expected to allow for the non-perturbative measurement of biological molecules in their native state, freely diffusing in solution.  The second platform involves interfacing a gold nanodisc array with solid supported lipid bilayers for label-free biosensing of membrane-associated proteins.  This platform is shown to have superior sensitivity due to elongated gold nanodics (exhibiting greater sensitivity than typical nanoparticle arrays) and an ultrathin silica layer above the nanodiscs, enabling the lipid bilayer to reside close to the nanoparticle surface.  Further studies currently underway are using this platform with silver nanodiscs to carry out label-free SERS measurements of lipid components in the freely diffusing bilayer.

August 31, 2017 | Neal Sullivan & Jeff Johnson

Fall Organizational Meeting, Research Ethics & Safety

September 7, 2017 | Office of Equity and Equal Opportunity & Miami University Police Department

Reporting Responsibilities and Campus Safety

September 14, 2017 | Melissa Lamson, BASF

September 21, 2017 | John Hutchison, Rice University

Silent Students in the Active Learning Classroom

September 28, 2017 | Amanda Hummon, University of Notre Dame

Imaging Mass Spectrometry of 3D Cell Cultures

October 5, 2017 | Rick Page, Miami University

Dynamic Protein Quality Control by the CHIP/Hsp70 Complex

October 12, 2017 | Erin Michele Dotlich, Eli Lilly

October 19, 2017 | Yujie Sun, Utah State University

Energy Catalysis: From Overall Water Splitting to Biomass Upgrading

October 26, 2017 | John Tansey, Otterbein University

November 2, 2017 | Malcom Forbes, Bowling Green State University

November 16, 2017 | Matt Francis, University of California at Berkeley (Gordon Lecturer)