
Eileen K. Bridge
Biography
Eileen K. Bridge is a virologist interested in studying how viruses manipulate host cell molecular mechanisms in order to promote their own replication. Her research and teaching focus on molecular mechanisms used by viruses and their host cells during their replication and growth. Her research has connections to both cancer biology and microbiology. Her teaching interests include the impact of microorganisms on human health, aspects of public health, and molecular mechanisms used by human cells and their viruses.
Education
- Ph.D. Johns Hopkins University, Biology, 1990
- B.A. Bennington College, Natural Science, 1981
Research Interests
Her research currently focuses on how adenovirus, a common cold virus, regulates the cellular DNA damage response. Future goals are to explore the possibility of using virus genes that regulate the DNA damage response, as tools to sensitize cancer cells to chemotherapy and/or radiation treatment.
Selected Publications
- Chen, C., and Bridge, E. 2022. DNA-PK phosphorylation at Ser2056 during adenovirus E4 mutant infection is promoted by viral DNA replication and independent of the MRN complex. Virology 565:82-95. doi: 10.1016/j.virol.2021.10.011.
- Kafle, C.M., Anderson, A.Y., Prakash, A., Swedik, S., and Bridge, E. 2022. An Adenovirus early region 4 deletion mutant induces G2/M arrest via ATM activation andreduces expression of the mitotic marker phosphorylated (ser10) histone 3. Virology 565:1-12. doi: 10.1016/j.virol.2021.09.006.
- Gautam, D., Stanley, G., Owen, M., and Bridge. E. 2019. Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers isimportant for its inhibitory effect on viral DNA accumulation. Virology 527:47-56.
- Gautam, D., and E. Bridge. 2013. The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication. J. Virol. 87:8687-8696.
- Prakash, A., Jayaram, S., and E. Bridge. 2012. Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirusmutants. J. Virol. 86:13324-13333.
- Mathew, S.S., and E. Bridge. 2008. Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication. Virology 374:11-22.
- Mathew, S.S., and E. Bridge. 2007. The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Virology 365:346-355.
- Bridge, E. 2007. Simultaneous detection of adenovirus RNA and cellular proteins by fluorescent labeling in situ. Methods Mol. Med. 131:63-72.
- Jayaram, S., and E. Bridge. 2005. Genome concatenation contributes to the late gene expression defect of an adenovirus E4 mutant. Virology 342:286-296.
- Corbin-Lickfett, K., and E. Bridge. 2003. Adenovirus E4-34kDa requires active proteasomes to promote late gene expression. Virology 315:234-244.
- Carter, C. C., R. Izadpanah and E. Bridge. 2003. Evaluating the role of CRM1-mediated export for adenovirus gene expression. Virology 315:224-233.
- Bridge, E. Mattsson, K., Aspegren, A. and A. Sengupta. 2003. Adenovirus early region 4 promotes the localization of splicing factors and viral RNA in late phase interchromatin granule clusters. Virology 311:40-50.
- Aspegren, A., and E. Bridge. 2002. Release of snRNP and RNA from transcription sites in Adenovirus-infected cells. Exp. Cell Res. 276: 273-283.
- Bridge, E. 2000. Letter to the Editor, Reply to: "The Nuclear Export Signal within the Adenovirus E4orf6 Protein Contributes to Several Steps in the Viral Life Cycle" J. Virol. 74:12000-12001.
- Rabino, C., A. Aspegren, K. Corbin-Lickfett and E. Bridge. 2000. Adenovirus late gene expression does not require a Rev-like Nuclear RNA export pathway. J. Virol. 74:6684-6688.
- Bridge, E. 1999. Simultaneous Detection of RNA and proteins in adenovirus-infected cells by fluorescence in situ hybridization (FISH) and immunostaining. In Methods in Molecular Medicine, Vol. 21: Adenovirus Methods and Protocols. Ed W.S.M. Wold, Humana Press inc., Totowa, NJ, USA. p231-240.
- Aspegren, A., C. Rabino, and E. Bridge. 1998. Organization of splicing factors in adenovirus-infected cells reflects changes in gene expression during the early to late phase transition. Exp. Cell Res. 245:203-213.
- Bridge, E., and U. Pettersson. 1996. Nuclear organization of adenovirus RNA biogenesis. Exp. Cell Res. 229:233-239.
- Bridge, E., K.-U. Riedel, B.-M. Johansson, and U. Pettersson. 1996. Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain. J. Cell Biol. 135:303-314.
- Bridge, E. and U. Pettersson. 1995. Nuclear organization of replication and gene expression in adenovirus infected cells. The molecular repertoire of adenoviruses I. Current Topics in Microbiology and Immunology. 199:99-117.
- Bridge, E., D.-X. Xia, M. Carmo-Fonseca, B. Cardinali, A. I. Lamond and U. Pettersson. 1995. Dynamic organization of splicing factors in adenovirus-infected cells. J. Virol. 69:281-290.
- Pombo A., J. Ferreira, E. Bridge and M. Carmo-Fonseca. 1994. Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells. EMBO J. 13:5075-5085.
- Bridge, E., M. Carmo-Fonseca, A.I. Lamond, and U. Pettersson. 1993. Nuclear organization of splicing snRNPs in adenovirus infected cells. J. Virol. 67:5792-5802.
- Bridge, E., S. Medghalchi, S. Ubol, M. Song, and G. Ketner. 1993. Adenovirus early region 4 and viral DNA synthesis. Virology 193:794-801.
- Bridge, E., C. Hemström, and U. Pettersson. 1991. Differential regulation of adenovirus late transcriptional units by the products of early region 4. Virology 183:260-266.
- Hemström, C., A. Virtanen, E. Bridge, G. Ketner, and U. Pettersson. 1991. Adenovirus E4 dependent activation of the early E2 promoter is insufficient to promote the early-to-late phase transition. J. Virol. 65:1440-1449.
- Bridge, E., and G. Ketner. 1990. Interaction of adenoviral E4 and E1b products in late gene expression. Virology 174:345-353.
- Ketner G., E. Bridge, A. Virtanen, C. Hemström, and U. Pettersson. 1989. Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Research 17:3037-3048.
- Bridge, E., and G. Ketner. 1989. Redundant control of adenoviral late gene expression by early region 4. J.
More publications can be viewed on the bibliography page of the National Library of Medicine website.
Courses Taught
- MBI 255 Modern Microbiology Applications
- MBI111 Microorganisms and Human Disease
- MBI131 Community Health
- MBI131H Community Health for honors students
- MBI147 Microbiology Introductory Seminar
- MBI464/564 Human Viruses
- BCMZ 493 Molecular Biology and Society
- MBI 490 Senior Seminar
- BCMZ603 CMSB First Year Seminar
- BMZ 605 Advanced Molecular Biology
- BMZ 606 Advanced Cell Biology
- BCM 650 Molecular Biology Seminar
- MBI 690 Microbiology Graduate Seminar