Center for Structural Biology and Metabonomics
The Center for Structural Biology and Metabonomics at Miami University is a pioneering research institution dedicated to advancing our understanding of complex biological systems. Through the integration of cutting-edge structural biology techniques and advanced metabolomics approaches, the center investigates the molecular intricacies of biological molecules and their interactions. With a focus on unraveling the relationship between structure and function, the center plays a vital role in driving breakthroughs in areas such as drug discovery, disease mechanisms, and personalized medicine.
Advanced Imagery, Advanced Discovery
The images below, obtained through collaborative efforts, showcase the remarkable capabilities of the Center's 850 MHz NMR spectrometer (pictured above) and the cutting-edge equipment at the Miami University Center for Advanced Microscopy and Imaging (CAMI), underscoring the power of interdisciplinary research in visualizing and understanding complex molecular structures.
Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens
PNAS September 7, 2021 118 (36) e2107963118; https://doi.org/10.1073/pnas.2107963118
Shenyuan Xu, Kristen Rose McGinnis, Yang Liu, Pengwei Huang, Ming Tan, Michael Robert Stuckert, Riley Erin Burnside, Elsa Grace Jacob, Shuisong Ni, Xi Jiang, Michael A. Kennedy
In collaboration with Dr. Xi (Jason) Jiang at Cincinnati Children's Hospital Medical Center.Read More
NMR spectroscopy and electron microscopy identification of metabolic and ultrastructural changes to the kidney following ischemia-reperfusion injury
Sponsored by the NIH
Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens
Shenyuan Xu, Luay U. Ahmed, Michael Robert Stuckert, Kristen Rose McGinnis, Yang Liu, Ming Tan, Pengwei Huang, Weiming Zhong, Dandan Zhao, and Michael A. Kennedy in collaboration with Xi (Jason) Jiang from Cincinnati Children's Hospital