Lori G. Isaacson


280 Pearson Hall  (513) 529-3142

Biographical Information

Lori Isaacson is a neuroscientist interested in the regulation of neuronal survival and the mechanisms of aging and neurodegeneration.  Specifically, she studies a) how growth factors called neurotrophins promote neuroprotection following injury by affecting the activities of glial cells and neurons in the central nervous system (CNS); b) the regulatory influences of the periphery on neuronal activities in the CNS; c) plasticity of glial cells and neurons in the spinal cord following peripheral nerve injury.  Students in her lab learn cellular and molecular techniques to examine the mechanisms underlying plasticity in the CNS following peripheral injury.

Research Interests

Mechanisms of neuronal survival
Communication between neurons and glial cells
Neuronal plasticity in the spinal cord

Courses Taught

Neuroanatomy (BIO 457/557), each spring
Human Anatomy (BIO 201), each fall and summer
Graduate Seminar in Neuroscience (BIO 710)

Recent Publications

Coulibaly, AP, MR Deer, LG Isaacson.  2014.  Distribution and phenotype of TrkB oligodendrocyte lineage cells in adult rat spinal cord. Brain Res 1582:21-33.

Coulibaly AP, SM Gannon, K Hawk, BF Walsh, LG Isaacson. 2013. Transection of preganglionic axons leads to CNS neuronal plasticity followed by survival and target reinnervation.  Autonomic Neuroscience 179:49-59.

Coulibaly AP, and LG Isaacson.  2012. Transient changes in spinal cord glial cells following transection of preganglionic sympathetic axons.  Autonomic Neuroscience 168(1-2):32-42.

Hesp ZC, Z Zhu, TA Morris, RG Walker, and LG Isaacson.  2012. Sympathetic reinnervation of peripheral targets following bilateral axotomy of the adult superior cervical ganglion.  Brain Research 473:44-54.