Andor J. Kiss

Adjunct Assistant Professor; Supervisor, Center for Bioinformatics and Functional Genomics

86C Pearson Hall  (513) 529-4280

Biographical Information

I am interested in adaptation and evolution from a vertically integrative perspective. My objectives are to understand how changes at the molecular level influence the success of the entire organism. Projects currently underway fall into three areas: (i) adaptive and evolutionary physiology of vertebrate animals, (ii) structure/function basis of long-term stability of globular protein systems and (iii) epigenomics and sensory systems in the acclimatory response. Experiments to elucidate these areas involve structural biochemistry of cold adapted lens crystallins and their evolutionary plasticity; how animal’s altered gene expression effects physiological adaptation to stress, such as extreme cold, low light, dehydration and anoxia. Lastly, we are focusing on seasonal queuing of the acclimatory response and how epigenetics may affect control mechanisms in both microbes and higher vertebrates.

In addition to my research interests, I oversee and manage the Center for Bioinformatics and Functional Genomics – which is Miami University’s DNA sequencing core and bioinformatics laboratory. We train many of the users on campus on most of the contemporary instrumentation used in molecular biology, as well as the basics of bioinformatics analysis pipelines.

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Recent Publications

Sellin-Jeffries, M.K., Kiss, A.J., Smith, A.W. and James T. Oris. (2014). A comparison of commercially-available automated and manual extraction kits for the isolation of total RNA from small tissue samples. BMC Biotechnology. (Accepted, October 2014)

Rosendale, A.J., Costanzo, J.P., Kiss, A.J. and Richard E. Lee, Jr. (2014). Identification and expression of a putative facilitative urea transporter in three species of true frogs (Ranidae): implications for terrestrial adaptation. Advances in Biology. Volume 2014 (2014), Article ID 148276, 11 pages. (Open Access).

Posner, M., Kiss, A.J., Skiba1, J., Drossman, A., Dolinska M.B., Hejtmancik, J.F. and Y. Sergeev. (2012). Functional Validation of Hydrophobic Adaptation to Physiological Temperature in the Small Heat Shock Protein αA-crystallin. PLoS ONE. 7: e34438. doi:10.1371¬/journal¬.pone.-0034438 (Open Access)

Kiss, A.J., Muir, T.J., Lee R.E. and Costanzo, J. (2011). Seasonal Variation in the Hepatoproteome of the Dehydration and Freeze-tolerant Wood Frog Rana sylvatica. International Journal of Molecular Sciences. 12(12), 8406-8414. doi:10.3390/ijms12128406 (Open Access).

Kiss, A.J. and Cheng, C.-H.C. (2008). Molecular Diversity and Genomic Organisation of the α, β and γ Eye Lens Crystallins from the Antarctic Toothfish Dissostichus mawsoni. Comparative Biochemistry and Physiology. Part D: Genomics and Proteomics. 3(2):155-171. http://dx.doi.-org/10.1016/j.cbd.2008.02.002