Michael L. Robinson

Professor

258 Pearson Hall  (513) 529-2353
robinsm5@miamioh.edu

Biographical Information

The Robinson Laboratory seeks to understand how cells differentiate during embryonic development and how those developmental choices are maintained through the life of an organism.  Virtually all animal life arises from a fertilized egg having the potential to develop into all the differentiated cell types needed for growth, organ development, respiration, digestion and reproduction.

The Robinson Lab creates and uses genetically engineered mice to answer fundamental developmental questions.  In particular, the laboratory maintains an interest in FGF/FGFR signaling in development and cancer.  Much of the research in the laboratory utilizes lens development as a system to study cell survival, differentiation and proliferation.  The laboratory is also currently supported by the NIH to investigate epigenetic regulation of lens development.


Courses Taught


Genetics (BIO 342)
Patterns in Development (BIO 361)


Recent Publications

Chaffee BR, Shang F, Chang ML, Clement TM, Eddy EM, Wagner BD, Nakahara M, Nagata S, Robinson ML and Taylor A. 2014. Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: Appropriating mitosis-related nuclear disassembly. Development 141:3388-3398.

Sellitto C. Li L, Gao J, Robinson ML, Lin RZ, Mathias RT and White TW. 2013. AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract. J Clin Invest. 123:5401-5409.

Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T and Mizushima N. 2013. Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem 288:11436-11447.

Madakashira BP, Kobrinski DA, Hancher AD, Arneman EC, Wagner BD, Wang F, Shin H, Lovicu FJ, Reneker LW and Robinson ML. 2012. Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development 139:4601-4612.

Qu X, Hertzler K, Pan Y, Grobe K, Robinson ML and Zhang X. 2011. Genetic epistasis between heparin sulfate and FGF-Ras signaling controls lens development.  Dev Biol 355:12-20.

Garcia CM, Huang J, Madakashira BP, Liu Y, Rajagopal R, Dattilo L, Robinson ML and Beebe DC. 2011. The function of FGF signaling in the lens placode. Dev Biol 351:176-185.

Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML and Leone G, 2011. Cell proliferation in the absence of E2F1-3. Dev Biol 351:35-45.