James Janik is a neuroendocrinologist whose primary interest is regulatory control of anterior pituitary hormone secretions. He is particularly interested in the neuroregulatory role played by the Endogenous Opioid Peptides and the recently discovered, novel neuropeptide, Orphanin FQ. Using the rat and knock-out mouse as their primary research models, students in his laboratory investigate mechanisms of hormonal control under several different physiological conditions at both the in vivo and in vitro levels. A major thrust of the work is determining the impact of gender and reproductive state, in particular lactation, on hormonal control mechanisms.
Prince-Zullig K.*, E. Murphree, R. Reinscheid, J. Janik and P. Callahan. Effect of Nociceptin/Orphanin FQ (N/OFQ) and isoflurane on the corticosterone secretory response in mice lacking the N/OFQ prepropeptide (ppN/OFQ-/-). Neuropeptides, 43(3):201-5 (2009).
Zullig,K.*, E. Murphree, R. Reinscheid, J. Janik and P. Callahan. Effect of orphanin OFQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice. Peptides, 28(8):1611-1614 (2007).
Kaur, G, J. Janik, L. Isaacson and P. Callahan. Estrogen regulation of neurotrophin expression in sympathetic neurons and vascular targets. Brain Research, 1139:6-14 (2007).
Chesterfield, M.*, J. Janik, E. Murphree, C. Lynn**, E. Schmidt** and P. Callahan. Orphanin FQ/Nociceptin (OFQ/N) is a physiological regulator of prolactin secretion in female rats. Endocrinology, 147(11): 5087-5093 (2006).
* Miami University Graduate Student
** Miami University Undergraduate Student