Kyle Timmerman

Kyle Timmerman

Associate Professor

Area: Exercise Science
Office: 26B Phillips Hall

Degree: Ph.D., Purdue University
M.S., Purdue University
B.S., Miami University | B.A., Miami University

Curriculum Vitae

Mental Health Ally Badge

Research Agenda

My scholarship focuses on the interactions among physical activity, inflammation, aging, and biomarkers of disease. It is known that higher levels of physical activity and/or exercise training exert anti-inflammatory effects in older adults. However, the mechanisms responsible for these effects are not well understood. Additionally, they are based almost exclusively on markers of inflammation in circulation, despite the fact that systemic inflammation is not necessarily reflective of the inflammatory milieu in other tissues (e.g. skeletal muscle). I believe that a number of molecular pathways, including aberrant toll-like receptor 4 (TLR4) and tumor necrosis factor alpha converting enzyme (TACE) expression/activity may contribute to skeletal muscle inflammation, wasting, insulin resistance and declines in function typically associated with aging. I further hypothesize that increased physical activity and/or exercise training can reduce skeletal muscle inflammation via reduced skeletal muscle expression and activation of TLR4 and its associated signaling proteins and ligands. A clearer understanding of the mechanisms responsible for the anti-inflammatory effects of exercise could provide inroads to improved preventive and therapeutic strategies targeting inflammatory-related chronic diseases such as cardiovascular disease, type II diabetes, sarcopenia, and cachexia.