Azizeh-Mitra (Amy) Yousefi, Ph.D.

Research Highlights

Research Interests

  • Biomaterials: scaffolds and nanocomposites for tissue engineering, cell-based gene therapy, and drug delivery
  • Numerical modeling: medical device design and industrial resin/part design, multiscale modeling
  • Structure-property relationships, materials characterization, polymer rheology, transport phenomena
  • Polymer processing: Extrusion Blow Molding, Injection Blow Molding, Thermoforming, Reactive Processing

Research Projects

  • Scaffolds for tissue engineering
Portrait of Dr. Azizeh-Mitra Yousefi

Professor

64M Engineering Building
513-529-0766
yousefiam@MiamiOH.edu
www.users.miamioh.edu/moshiray/

Degrees

  • Ph.D.—Chemical Engineering, École Polytechnique, University of Montreal, QC, Canada—1996
  • M.S.—Chemical Engineering, Amir Kabir University (Tehran Polytechnic), Tehran, Iran—1990
  • B.S.—Polymer Engineering, Amir Kabir University (Tehran Polytechnic), Tehran Iran—1988

Research Funding

  • National Institute of Health (NIH-NIAMS)
  • Ohio Board of Regents (OBR)

Experience

  • Spooner Schallek Associate Professor, Miami University, Oxford, OH (2009–present)
  • Visiting Faculty, Chemical and Biomolecular Engineering, Vanderbilt University, TN (fall 2015)
  • Visiting Faculty, Sciences Chimiques, University of Rennes 1, Rennes, France (June 2015)
  • Visiting Faculty, Department of Chemical Engineering, University of Michigan, MI (fall 2011)
  • Research Officer, National Research Council of Canada, Industrial Materials Institute, QC (2001–2009)
  • Associate Researcher, Orthopedics Pavilion, Montreal's  Sacré-Coeur Hospital, Montral, QC (2007–2009)
  • Research Associate, National Research Council of Canada, Industrial Materials Institute, QC (1999–2001)
  • Postdoctoral Associate, Applied Mathematics, Ecole Polytechnique, University of Montreal, QC (1997–1999)
  • Researcher, GIC Polymer Research Lab, Tehran, Iran (1988–1992)

Professional Memberships

  • Society of Plastics Engineers
  • BioOhio
  • Society for Biomaterials
  • International Society for Cell Therapy
  • Tissue Engineering and Regenerative Medicine International Society
  • Society for Stimulation in Healthcare

Professional Services

  • 2015–Present Reviewer, European Research Network in Materials Science and Engineering (M-ERA.NET)
  • 2014–Present Reviewer, National Science Foundation (NSF), Graduate Research Fellowship Program (GRFP)
  • 2014–Present Editorial Board Member, Journal of Chemical Engineering Research Studies
  • 2014–Present Editorial Board Member, International Journal of Radiology
  • 2007–Present Reviewer: International Journal for Numerical Methods in Biomedical Engineering; Journal of Biomedical Materials Research: Part B; Journal of Biotechnology and Bioengineering; Tissue Engineering: Part A; Recent Patents on Medical Imaging; Journal of Biomaterials Science-Polymer Edition; Polymer Engineering and Science
  • 2010–2014 Reviewer (NIH), Biomaterials and Biointerfaces Study Section (BMBI)
  • 2012–2013 Reviewer (NIH), Bioengineering Science and Technologies Study Section (BST)
  • 2011–2013 Reviewer (NIH), Biomaterials, Delivery Systems, and Nanotechnology (IMST-13)
  • 2014 Consultant, Automotive Industry
  • 2012 Reviewer (NIH), Microphysiological Systems Study Section
  • 2011 Reviewer (NSF), Polymers Program (POL)
  • 2008 Reviewer, National Sciences and Engineering Research Council of Canada (NSERC, IRDF)
  • 2008 Co-Head, SigBlow Consortium, National Research Council of Canada (NRC)
  • 2007 Session Chair, Properties of Cells and Tissues for Simulation, SSH CompMed Conference
  • 2007 Session Chair, Keynote Speakers, SPE Annual Blow Molding Conference, Montreal
  • 2005 Head, SigForm Consortium, National Research Council of Canada (NRC)
  • 2003 Session Chair, Thermoforming Session, SPE ANTEC Annual Conference, Nashville

Honors and Awards

  • Spooner Schallek Endowed Chair, Miami University, Oxford, OH (2009-Present )
  • Nomination for the Arthur Olson Generational Teaching Excellence Award, Miami University (2014, 2015)
  • Recipient of “l’ordre du mérite” (team), National Research Council of Canada (NRC-IMI), QC (2006)
  • Recipient of “l’ordre du mérite”, National Research Council of Canada (NRC-IMI), QC (2002) 

Principal Publications

Chapters

  • Yousefi AM, Drapaca CS, Kazina CJ (2015). “Cryogel Tissue Phantoms with Uniform Elasticity for Medical Imaging”, in Supermacroporous Cryogels: Biomedical and Biotechnological Applications; Kumar A, Ed., Taylor & Francis; CRC Press. Link
  • Yousefi AM* (2016). “Smart Functional Porous Materials for Tissue Engineering”, in “Fundamental Principles of Smart Materials in Tissue Engineering”, Chapter 13 (pp. 358-400), Wang Q, Ed.; *Royal Society of Chemistry*. ISBN: 978-1-78262-464-6, Link

Software Packages

  • TSBM© software for the simulation of twin-sheet blow molding; NRC, 2006 – 2009.
  • BlowParison© software for the simulation of viscoelastic parison swell (fuel tank design), NRC, 2000 – 2009.

Peer-Reviewed Papers

  • Uth N, Mueller J, Smucker B, *Yousefi AM* (2017). Validation of Scaffold Design Optimization in Bone Tissue Engineering: Finite Element Modeling versus Designed Experiments. *Biofabrication*; 9(1):015023. Abstract
  • Yousefi AM, James PF, Akbarzadeh R, Subramanian A, Flavin C, Oudadesse H (2016). “Prospect of Stem Cells in Bone Tissue Engineering”; Stem Cells International, Volume 2016, Article ID 6180487, 13 pages. Abstract
  • Yousefi AM, Oudadesse H, Akbarzadeh R, Wers E, Lucas-Girot A (2014). “Physical and Biological Characteristics of Nanohydroxypatite and Bioactive Glasses used for Bone Tissue Engineering” Nanotechnology Reviews; 3:527–552. Abstract
  • Akbarzadeh R, Minton J, Janney C, Smith T, James PF, Yousefi AM (2015). “Hierarchical Polymeric Scaffolds Support the Growth of MC3T3-E1 Cells”, Journal of Material Science: Materials in Medicine, 26(116):1-12. Abstract (highlighted by the Global Medical DiscoveryJune 2015)
  • Yousefi AM, Hoque ME, Prasa RGSV, Uth N (2014). “Current Strategies in Multiphasic Scaffold Design for Osteochondral Tissue Engineering”, Journal of Biomedical Materials Research: Part A, 103(7):2460-81. Abstract
  • Minton J, Janney C, Akbarzadeh R, Focke C, Subramanian A, Smith T, McKinney J, Liu J, Schmitz J, James PF, Yousefi AM. (2014). “Solvent-free Polymer/Bioceramic Scaffolds for Bone Tissue Engineering: Fabrication, Analysis, and Cell Growth”, Journal of Biomaterials Science: Polymer Edition, 25:1856-74. Abstract
  • Yousefi AM, Drapaca CS, Kazina CJ (2014). “Cryogel Tissue Phantoms with Uniform Elasticity for Medical Imaging”, in “Supermacroporous Cryogels: Biomedical and Biotechnological Applications”; Taylor & Francis; CRC Press (in press).
  • Yousefi AM, Oudadesse H, Akbarzadeh R, Wers E, Lucas-Girot A (2014). “Physical and Biological Characteristics of Nanohydroxypatite and Bioactive Glasses used for Bone Tissue Engineering” Nanotechnology Reviews. Abstract
  • Minton J, Janney C, Akbarzadeh R, Focke C, Subramanian A, Smith T, McKinney J, Liu J, Schmitz J, James PF, Yousefi AM. (2014). “Solvent-free Polymer/Bioeramic Scaffolds for Bone Tissue Engineering: Fabrication, Analysis, and Cell Growth”, Journal of Biomaterials Science: Polymer Edition. Abstract.
  • Akbarzadeh R, Yousefi AM (2014). “Effects of Processing Parameters in Thermally Induced Phase Separation Technique on Porous Architecture of Scaffolds for Bone Tissue Engineering”, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102(6):1304-15. Abstract.
  • Iravani A, Mueller J, Yousefi AM (2014). “Producing Homogeneous Cryogel Phantoms for Medical Imaging: A Finite-Element Approach”, Journal of Biomaterials Science: Polymer Edition, 25:181-202. Abstract.
  • Yousefi AM, Hoque ME, Prasa RGSV, Uth N (2014). “Current Strategies in Gradient-based Scaffold Design for Osteochondral Tissue Engineering”, submitted to Journal of Biomedical Materials Research: Part A.
  • Akbarzadeh R, Minton J, Smith T, Janney C, James PF, Yousefi AM (2014). “Hierarchical Macro/Microporous Scaffolds Support the Growth of MC3T3-E1 Cells”, submitted to Journal of Material Science: Materials in Medicine.
  • Yousefi AM, Love BJ (2013). “Probing the Temperature Sensitivity of Induction Time in Latent Cure Epoxy Resins”. Polymer International, 62:1451-1456.
  • Minton JA, Iravani A, Yousefi AM (2012) “Improving the Homogeneity of Tissue-mimicking Cryogel Phantoms for Medical Imaging”, Medical Physics, 39:6796-6807. Abstract
  • Yousefi AM, Zhou Y, Querejeta-Fernández A, Sun K, Kotov NA (2012). “Streptavidin Inhibits Self-Assembly of CdTe Nanoparticles”, Journal of Physical Chemistry Letters, 3:3249-3256. Abstract
  • Coutu DL, Cuerquis J, El-Ayoubi R, Forner KA, Roy R, François M, Griffith M, Lillicrap D, Yousefi AM, Blostein MD, Galipeau J (2011). “Hierarchical Scaffold Design for Mesenchymal Stem Cell-Based Gene Therapy of Hemophilia B”, Biomaterials, 32:295-305. Abstract 
  • El-Ayoubi R, De Grandpré C, DiRaddo R, Azizeh-Yousefi AM, Patrick Lavigne (2011). “Design and Dynamic Culture of 3D Scaffolds for Cartilage Tissue Engineering”, Journal of Biomaterials Applications, 25:429-444. Abstract
  • Coutu DL, Yousefi AM, Galipeau J (2009). “Three Dimensional Porous Scaffolds at the Crossroads of Tissue Engineering and Cell-Based Gene Therapy”, Journal of Cellular Biochemistry, 108:537-546. Abstract 
  • Stosich MS, Moioli EK, Wub JK, Lee CH, Rohde C, Yousefi AM, Ascherman J, Diraddo R, Marion NW, Mao JJ (2009) “Bioengineering Strategies to Generate Vascularized Soft Tissue Grafts with Sustained Shape”, Methods, 47: 116-121. Abstract 
  • Yousefi AM, den Doelder J, Rainville M-A, Koppi KA (2009). “A Modeling Approach to the Effect of Resin Characteristics on Parison Formation in Extrusion Blow Molding”, Polymer Engineering and Science, 49:251-263.      Abstract 
  • Yousefi AM, Atsbha H (2009). “Modeling of Complex Parison Formation in Extrusion Blow Molding: Medium to Large Die-Head Size and Fuel Tank Geometry”, Polymer Engineering and Science, 49:229-239. Abstract 
  • El-Ayoubi R, Eliopoulos N, DiRaddo R, Galipeau J, Yousefi AM (2008). “Design and Fabrication of 3D Porous Scaffolds to Promote Cell-Based Gene Therapy”, Tissue Engineering, 14:1037-1048. Abstract 
  • Yousefi AM (2008). “3D Scaffolds Deliver Tissue Growth”, NRC Newslink, summer issue, page 5. Abstract 
  • Yousefi AM, Gauvin C, Sun L, DiRaddo RW, Fernandes J (2007). “Design and Fabrication of 3D-Plotted Polymeric Scaffolds in Functional Tissue Engineering”, Polymer Engineering and Science, 47:608-618. Abstract 
  • Yousefi AM, Collins P, Chang S, DiRaddo RW (2007). “A Comprehensive Experimental Study and Numerical Modeling of Parison Formation in Extrusion Blow Molding”, Polymer Engineering and Science, 47:1-13. Abstract 
  • Yousefi AM, Laroche D, Collins P, DiRaddo R (2003). “A New Hybrid Approach for the Prediction of Parison Swell in Extrusion Blow molding”, SPE Blow Molding Newsletter, Spring Edition, 4-5. 
  • Yousefi A, Bendada A, Diraddo R (2002). “Improved Modeling for the Reheat Phase in Thermoforming through an Uncertainty Treatment of the Key Parameters”, Polymer Engineering and Science, 42:1115-1129. Abstract 
  • Yousefi A, Lafleur PG, Gauvin R (1997). “Numerical Analysis of Promoted Polyester and Vinylester Reinforced Composites in RTM Molds”, Polymer Engineering and Science, 37:757-771. Abstract 
  • Yousefi A, Lafleur PG, Gauvin R (1997). “The Effects of Cobalt Promoter and Glass Fibers on the Curing Behavior of Unsaturated Polyester Resin”, Journal of Vinyl Additives Technology, 3:157-169. Abstract 
  • Yousefi A, Lafleur PG, Gauvin R (1997). “Kinetic Studies of Thermoset Cure Reactions - A Review”, Polymer Composites, 18:157-168. Abstract 
  • Yousefi A, Katbab AA (1994). “Post Irradiation Degradation of Polypropylene, Radiation Durability of Polypropylene Stabilized with Phenolic Stabilizer (II)”, Radiation Physics and Chemistry, 44:645-651. 
  • Hassanpour S, Yousefi A (1993). “Radiation Stabilization of Polypropylene by Phenolic Stabilizers”, Radiation Physics and Chemistry, 42:223-227. 
  • Katbab AA, Moushirabadi AY (1991). “Post-Irradiation Degradation of Polypropylene: Comparison of Hindered Aromatic Phenol and Amine as Gamma Stabilizer-I”, Radiation Physics and Chemistry, 38:295-301. 

Conferences

  • Flavin C, Ferriell D, Focke C, Subramanian A, Akbarzadeh R, Sheppard R, James PF, Yousefi AM (2015). “Polymer-Ceramic Scaffolds Produced by Solid Freeform Fabrication/Thermally-Induced Phase Separation”, SPE-ANTEC, Orlando, FL, March 23-25 (5 pages). (Best Presentation Award)
  • Yousefi AM, Szekely S, Shaw C, Reichenbach K, Naber A, Janney C, Focke C, Smucker B (2015). “Modulating the Porosity and Modulus of Tissue Engineering Scaffolds in Fused Deposition Modeling”, SPE-ANTEC, Orlando, FL, March 23-25 (5 pages).
  • Minton J, Janney C, Focke C, Yousefi AM (2013). “Design and Fabrication of Polymer/Ceramic Scaffolds for Bone Tissue Engineering” (6 pages), SPE-ANTEC, Cincinnati, OH, April 22-24.
  • Akbarzadeh R, Hagen M, Yousefi AM (2013). “Developing Polymer/Ceramic Scaffolds via Thermally Induced Phase Separation for Bone Tissue Engineering” (4 pages), SPE-ANTEC, Cincinnati, OH, April 22-24.
  • Yousefi AM, Mueller J (2013). “The Effect of Resin Viscoelasticity on Extrudate Swell: Computational Modeling and Experimental Validation” (5 pages), SPE-ANTEC, Cincinnati, OH, April 22-24
  • Yousefi AM, Akbarzadeh R, Minton J, Ferriell D, Focke C, Flavin C, James PF (2014). “Hierarchical Macro/Microporous 3D Scaffolds Support the Growth of MC3T3-E1 Osteoblastic Cells”, The Society for Biomaterials Annual Meeting, Denver, CO, April 16-19.
  • Yousefi AM, Focke C, Janney C, Naber A, Reichenbach K, Shaw C, Szekely S, Taylor L, Smucker B (2014). “I-Optimal Design and Topology Control of 3D Scaffolds Produced by Fused Deposition Modeling”, The Society for Biomaterials Annual Meeting, Denver, CO, April 16-19.
  • Akbarzadeh R, Hagen M, Smith T, James PF, Yousefi AM, (2013). “Hierarchical Scaffolds Produced by a Hybrid Solid Freeform Fabrication/Thermally-Induced Phase Separation Technique”, The 2nd International Materials Science Conference, Las Vegas, NV, October 7-10.
  • Minton JA, Janney CS, Focke C, Akbarzadeh R, James PF, Yousefi AM (2013). “The Effect of Polymer/Ceramic Scaffold Architecture and Composition on the Growth of MC3T3 Osteoblastic Cell Line, The 2nd International Materials Science Conference, Las Vegas, NV, October 7-10.
  • Minton JA, Janney CS, Yousefi AM (2012). “A Novel Technique to Produce Solvent-Free Scaffolds for Tissue Engineering”, The World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), Vienna, Austria, September 5-8.
  • Yousefi AM, Chander K, Minton J (2011). “Modulating Viscoelasticity of Biomaterials for Cartilage Regeneration and Cartilage Replacement”, 4th International Conference on the Mechanics of Biomaterials and Tissues (ICMBT), Hawai’i, HI, December 11-15.
  • Yousefi AM, Minton JA, Ananth R, Neuberger T, Lanagan MT, Drapaca CS (2011). “Tissue-mimicking Gel Phantoms for Brain Tumour Detection using Magnetic Resonance Modalities”, 4th International Conference on the Mechanics of Biomaterials and Tissues (ICMBT), Hawai’i, HI, December 11-15.
  • Yousefi AM, Minton J, Drapaca C (2011). “Towards Biomimetic Tissue Phantoms for Brain Tumor Detection using Magnetic Resonance Elastography”, The Society for Biomaterials Annual Meeting, Orlando, FL, April 13-16.
  • Yousefi AM (2011). “Scaffold Design for Functional Tissue Engineering and Cell-Based Gene Therapy Applications”, The Society for Biomaterials Annual Meeting, Orlando, FL, April 13-16.
  • Yousefi AM, Janssen M, Tan QW, Holland Z, Leszczak V, McCormick A, Cornick A (2010). “Towards Multiscale Performance Prediction for Tissue Engineering Scaffolds”, Annual Meeting of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), Orlando, FL, Dec. 5-8.
  • Holland Z, Janssen M, Cornick A, McCormick A, Tan Q W, Leszczak V, Yousefi AM (2010). “3D-Printed Scaffolds for Tissue Engineering and Cell-Based Gene Therapy”, 16th Annual Congress of the International Society for Cellular Therapy (ICST), Philadelphia, PA, May 23-26

Invited-Keynote Talks

  • Yousefi AM (2014). “Additive Manufacturing of Viscoelastic Polymers: Opportunities & Challenges”, Ohio Innovation Summit for Sensing – Meeting of Ohio Research Scholars of OARCLS, Dayton (Invited), Oct. 7–9.
  • Yousefi AM (2014). “Computational Design: An Overview of Some Industrial and Biomedical Case Studies”, Wright-Patterson Air Force Base (WPAFB), Dayton, OH.
  • Yousefi AM (2013). “Numerical Modeling in Polymer Processing”, Ford Motor Company, MI.
  • F. Thibault, A.M. Yousefi, H. Atsbha, R. DiRaddo, “Modeling of Parison Formation and Process Optimization for Blow Molded Parts”, PPS-22 (Keynote Speaker), Yamagata, July 2-6, 2006.
  • A.M. Yousefi, “Deformable Biostructures”, Seminar at Johnson & Johnson Center for Biomaterials & Advanced Technologies (Invited Speaker), Newark, Jan. 17, 2006.
  • A.M. Yousefi, “Overview of Research Activities at IMI-NRC”, Seminar at the University of Michigan (Invited Speaker), Ann Arbor, April 2004.
  • A. Yousefi, “New Approaches to the prediction of the Injection Stretch Blow Moulding of PET: Reheat to Stretch/Inflation to Part Solidification”, NOVA-PACK AMERICAS 2003 (Invited Speaker), Feb. 3-4, Orlando, 2003. 
  • A. Yousefi, “Computer Simulation of Blow Molding”, High Production Blow Molding Workshop (Invited Speaker), Aug. 27-29, Michigan, 2001.

Patents

  • A.M. Yousefi, C. DeGrandpré, R. El-Ayoubi, “Tissue Scaffold and Method of Fabrication Thereof”, U.S. Provisional Patent, 60/817,427 (2006).
  • G. Maurais, N. Huynh, R. DiRaddo, J. Fernandes, S. Delorme, and , A. Yousefi,“Methods for Regenerating Fractured and/or Diseased Vertebra”, Provisional Patent, IPS 11667 (April 29, 2005).