Anna Radke

Radke Fall 2016

Assistant Professor

112 Psychology Building
Oxford, OH 45056
513-529-6941
aradke@MiamiOH.edu
RAD Lab/a>

Throughout my training I have gained considerable experience in rodent measures of behavior, with a specific focus on motivational brain systems. Techniques and measures I have experience with include operant responding for food/drug/electrical stimulation, fear conditioning and measures of anxiety, measures of drug withdrawal, in vivo fast scan cyclic voltammetry to measure dopamine release, and opto/chemogenetic control of behavior. Additionally, I have a strong interest in mentoring undergraduate and graduate students in the lab.

Education

  • Postdoctoral Fellowship, National Institutes of Health 2012-2016
  • PhD, University of Minnesota, 2011
  • BA, St. Olaf College, 2006

Teaching Interests

Biopsychology, Psychopharmacology, Neuroscience

  • 251 | Introduction to Biopsychology
  • 410A | Capstone in Neuroscience
  • 456/556 | Biological Bases of Behavior

Research Interests

In the Reward and Addictive Disorders (RAD) Lab we use animal models to study motivational brain circuits on a systems level. Our goal is to understand how these neural circuits function in a healthy state as well as to uncover adaptations that contribute to maladaptive behaviors such as addiction. Currently we are investigating glutamatergic and dopaminergic contributions to compulsive-like behaviors such as inflexible alcohol drinking in mice. Our principle experimental approaches include manipulating behavior with pharmacological, genetic, and chemogenetic tools and measuring changes in dopamine release with fast scan cyclic voltammetry.

Professional Recognition

  • Postdoctoral Mentor Award, National Institutes of Health (2013, 2014, 2015)
  • NIDA Predoctoral Training Grant in Pharmaconeuroimmunology, University of Minnesota (2010-2011)
  • NICHD Predoctoral Training Grant in Cognitive Sciences, University of Minnesota (2007-2010)
  • Charles and Dorothy Bird Award for outstanding research, Sigma Xi, University of Minnesota (2009)

Selected Publications

  • Radke AK, Jury NJ, Delpire E, Nakazawa K, Holmes A. (2017). Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptor subunit. Alcohol 58:47-51.
  • Radke AK, Jury NJ, Kocharian AK, Marcinkiewcz CA, Lowery-Gionta EG, Pleil KE, McElligot ZA, McKlveen JM, Kash TL, Holmes A. (2017). Chronic EtOH effects on putative measures of compulsive behavior in mice. Addiction Biology 22:423-434.
  • Brigman J, Izquirdo A, Radke AK, & Holmes A. (2017). The neural basis of reversal learning: An updated perspective. Neuroscience 345:12-26
  • Radke AK, Nakazawa K, Holmes A. (2015). Cortical GluN2B deletion attenuates punished suppression of food reward-seeking.Psychopharmacology 232: 3753-3761.
  • Radke AK, Pickens CL, Holmes A. (2014). The effects of stress on measures of alcohol drinking in rodents. In: Noronha ABC, Cui C, Harris RA, and Crabbe JC (eds.) Neurobiology of Alcohol Dependence, pp. 97-110 Oxford: Academic Press.

View a complete list of publications

Grants

  • Miami University, Committee on Faculty Research grant, Defining the neural circuits responsible for opioid reward and aversion, $38,700, in progress
  • Miami University, Office for the Advancement of Research and Scholarship grant, Preliminary data on the neurobiological mechanisms of opioid abuse, $15,270, in progress
  • Miami University, College of Arts and Sciences, Do dopamine neurons contribute to compulsive alcohol-drinking?, $5,000, completed June 2017

Research Lab Information

Undergraduate students interested in joining the Reward and Addictive Disorders lab should fill out an application at www.aradlab.com/contact.

Interested graduate students should contact Dr. Radke directly.