Anna Radke

Radke Fall 2016

Assistant Professor

112 Psychology Building
Oxford, OH 45056
513-529-6941
aradke@MiamiOH.edu

I am trained as a behavioral neuroscientist and my research focuses on motivational brain systems. My lab uses mouse models of behavior to study positive and negative motivational states, specifically as they relate to psychiatric disorders and addiction. I earned a BA in Biology from St. Olaf College and a PhD in Neuroscience from the University of Minnesota. Prior to joining the faculty at Miami in 2016, I completed a postdoctoral fellowship at the National Institute on Alcohol Abuse and Alcoholism. I have a strong interest in mentoring undergraduate and graduate students in research.

Education

  • Postdoctoral Fellowship, National Institutes of Health 2012-2016
  • PhD, University of Minnesota, 2011
  • BA, St. Olaf College, 2006

Teaching Interests

I teach Biopsychology and Neuroscience courses in the Psychology department. I enjoy exposing students to the workings of the brain and teaching students to be critical consumers of scientific information.

  • 251 | Introduction to Biopsychology
  • 356 | Psychopharmacology
  • 410A | Capstone in Neuroscience
  • 456/556 | Advanced Biological Bases of Behavior

Research Interests

In the Reward and Addictive Disorders (RAD) Lab, we use animal models to study motivational brain circuits on a systems level. Our goal is to understand how these neural circuits function in a healthy state as well as to uncover adaptations that contribute to maladaptive behaviors such as addiction. Currently, we are investigating glutamatergic and dopaminergic contributions to compulsive-like behaviors such as inflexible alcohol drinking in mice. Our principle experimental approaches include manipulating behavior with pharmacological, genetic, and chemogenetic tools.

Professional Recognition

  • Alumni Teaching Scholar, Miami University (2019-2020)
  • Postdoctoral Mentor Award, National Institutes of Health (2013, 2014, 2015)
  • Charles and Dorothy Bird Award for outstanding research, Sigma Xi, University of Minnesota (2009)

Selected Publications

  • Monroe SC* & Radke AK. (2020). Aversion-resistant fentanyl self-administration in mice. Psychopharmacology. doi: 10.1007/s00213-020-05722-6
  • Sneddon EA*, Ramsey OR**, Thomas AM**, Radke AK. (2020). Increased responding for alcohol and resistance to aversion in female mice. Alcoholism: Clinical and Experimental Research. doi: 1111/acer.14384
  • Radke AK, Held IT**, Sneddon EA*, Riddle CA**, Quinn JJ. (2019). Additive influences of acute early life stress and sex on vulnerability for aversion-resistant alcohol drinking. Addiction Biology. doi: 1111/adb.12829
  • Sneddon EA*, White RD**, Radke AK. (2019). Sex differences in binge-like alcohol drinking and resistance to aversion in C57BL6/J mice. Alcoholism: Clinical and Experimental Research 43: 243-249.
  • Radke AK, Kocharian AK, Covey DP, Lovinger DM, Cheer JF, Mateo Y, Holmes A. (2019). Contributions of nucleus accumbens dopamine to cognitive flexibility. European Journal of Neuroscience 50: 2023-2035.
  • Radke AK, Jury NJ, Delpire E, Nakazawa K, Holmes A. (2017). Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptor subunit. Alcohol 58:47-51.
  • Radke AK, Jury NJ, Kocharian AK, Marcinkiewcz CA, Lowery-Gionta EG, Pleil KE, McElligot ZA, McKlveen JM, Kash TL, Holmes A. (2017). Chronic EtOH effects on putative measures of compulsive behavior in mice. Addiction Biology 22:423-434.
  • Brigman J, Izquirdo A, Radke AK, & Holmes A. (2017). The neural basis of reversal learning: An updated perspective. Neuroscience 345:12-26
  • Radke AK, Nakazawa K, Holmes A. (2015). Cortical GluN2B deletion attenuates punished suppression of food reward-seeking.Psychopharmacology 232: 3753-3761.

*Miami graduate student  **Miami undergraduate student

View a complete list of publications

Grants

  • R15 Academic Research Enhancement Award, National Institute on Alcohol Abuse and Alcoholism, Analysis of subcortical networks that promote aversion-resistant alcohol dirnking, $378,136, 2020-2023
  • Miami University, Committee on Faculty Research grant, Defining the neural circuits responsible for opioid reward and aversion, $38,700, 2018-2019
  • Miami University, Office for the Advancement of Research and Scholarship grant, Preliminary data on the neurobiological mechanisms of opioid abuse, $15,270, 2018-2019
  • Miami University, College of Arts and Sciences, Do dopamine neurons contribute to compulsive alcohol-drinking?, $5,000, 2017

Research Lab Information

Undergraduate students interested in joining the Reward and Addictive Disorders lab should fill out an application at www.aradlab.com/contact.

Interested graduate students should contact Dr. Radke directly.

RAD Lab

Dr. Radke leads the Reward and Addictive Disorders Lab

Learn more about the RAD Lab