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A74 - Discovery and classification of novel transcript isoforms in the chicken genome
Chicken (Gallus gallus) is both a key model organism and a species of major agricultural significance, yet their genome annotation remains incomplete due to limited RNA sampling across diverse tissues, developmental stages, and conditions.
A74 - Discovery and classification of novel transcript isoforms in the chicken genome
Mentor: Chun Liang, Ph.D.
Chicken (Gallus gallus) is both a key model organism and a species of major agricultural significance, yet their genome annotation remains incomplete due to limited RNA sampling across diverse tissues, developmental stages, and conditions. Transcript isoforms, which are distinct mRNA versions that arise from the same gene via alternative splicing, promoter usage, or polyadenylation. They greatly expand proteomic diversity while playing critical roles in gene regulation. Abnormal isoform expression is implicated in cancer, neurological disorders, and cardiovascular disease, underscoring the importance of accurate isoform characterization. Using bulk RNA-seq data, this study aims to identify novel transcript isoforms in the chicken genome through comprehensive gene and transcript-level analysis. We expect this approach to uncover previously unannotated isoforms, advancing our understanding of gene regulation, phenotypic diversity, and functional complexity in Gallus gallus.