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A82 - D1RL Antagonism Following Morphine Sensitization in Adolescent Pb-exposed Mice
Lead (Pb) is a neurotoxin that can leak from aging pipes into drinking water, disproportionately harming disadvantaged communities and demanding stronger protective legislation.
A82 - D1RL Antagonism Following Morphine Sensitization in Adolescent Pb-exposed Mice
Mentor: Anna Radke, Ph.D.
Lead (Pb) is a neurotoxin that can leak from aging pipes into drinking water, disproportionately harming disadvantaged communities and demanding stronger protective legislation.
Exposure to toxic Pb concentrations (300 mg/L) in C57BL/6 mice produces increases in locomotor behavior.
Repeated administration of morphine produces dopaminergic sensitization. The D1-class receptor antagonist, SCH 23390 HCl, blocks morphine-induced hyperactivity.
We hypothesized that adolescent Pb exposure would disrupt mice’s time spent in the center zone, locomotor response to initial morphine exposure, morphine sensitization, and D1-class receptor antagonism via SCH 23390 HCl.