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B61 - The Effects of Cholinergic Mu-Opioid Receptor Modulation on Preference and Reward
Opioid Use Disorder (OUD) is a critical and escalating public health crisis in the United States, affecting approximately 6.1 million Americans aged 12 or older.
B61 - The Effects of Cholinergic Mu-Opioid Receptor Modulation on Preference and Reward
Mentor: Anna Radke, Ph.D.
Opioid Use Disorder (OUD) is a critical and escalating public health crisis in the United States, affecting approximately 6.1 million Americans aged 12 or older.
● Acetylcholine (ACh) from cholinergic interneurons (CIN) in the nucleus accumbens (NAc) plays an important role in neural responses and adaptation, underlying cocaine reinforcement and addiction.
● Acetylcholine (ACh) released from CINs triggers dopaminergic axon activity, reinforcing addictive behaviors.
● Previous studies have shown that activation of mu-opioid receptors (MORs) in the striatum inhibits cholinergic interneurons.
●This study aims to discover the role that mu-opioid receptors (MORs) play within cholinergic interneurons within the context of opioid use disorder, specifically for reward and reinforcement.